HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1-(3-Difluoromethyl-4-fluoro-phenyl)-1H-imidazole-4-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | Ethyl nitroacetate | HCID 69379 | — |
| Reactant | 3-(Difluoromethyl)-4-fluoroaniline | HCID 23445076 | — |
| Catalyst | Iron | HCID 23925 | — |
| Product | 1-(3-Difluoromethyl-4-fluoro-phenyl)-1H-imidazole-4-carboxylic Acid | HCID 23445129 | — |
Reaction Steps
Following the general method described in example 234, 3-difluoromethyl-4-fluoroaniline was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The title compound was obtained as a light brown crystalline solid. Mp.>247° C. dec. (H2O/dioxane), MS: m/e=255 (M−H−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06610723B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-c7027868dbfb4853b39202a738494c66 |
| Source note | uspto-grants-2003_08 |