Aluminium lithium hydride → HCID 23445193, compound

HRID 397937Notes

Reaction equation

HRID 397937 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[CH:8][N:9]([C:11]2[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]=2)[CH:10]=1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[N:12]1[C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:19]=[CH:20][C:11]=1[N:9]1[CH:10]=[C:6]([CH2:4][OH:3])[N:7]=[CH:8]1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 69042178HCID 69042178, compound

Product 1

HCID 23445193HCID 23445193, compound

Procedure

Following the general method described in example 298, 1-quinolin-2-yl-1H-imidazole-4-carboxylic acid ethyl ester was reacted with lithium aluminum hydride followed by hydrolytic workup and chromatography. The title compound was obtained as an off-white crystalline material. Mp. 136-137° C. (EtOH), MS: m/e=225 (M+).

Sources & evidence

ORD record
ord-09b64a8f18eb4c52a0a6b69d61c86e6b
Source dataset
uspto-grants-2003_08
Patent number
US06610723B2

Reaction notes

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