Potassium Carbonate → HCID 54509916, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2,6-dichloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine ** (10.1 g, 22.6 mM), iso-propanol (300 ml), K2CO3 (5 g) and 1-ethylpropylamine (2.17 g, 24.84 mM) was stirred at 20 C. for 24 hrs. The reaction mixture was heated at 54° C. for 73 hrs. Solvent was removed in vacuo, water (50 ml) was added, extracted with ethyl acetate (3×80 ml), the combined extracts were dried (MgSO4) affording the title compound as a creamy light brown foam (9.44 g). LC/MS system A Rt=2.66 min, m/z=372 MH+.

Provenance & Evidence