2-Morpholinoethylamine → (2r,3r,4s,5s)-2-[6-(1-Ethyl-propylamino)-2-(2-morpholin-4-yl-ethylamino)-purin-9-yl]-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-tetrahydro-furan-3,4-diol formate

関与物質

反応条件

反応手順

Intermediate 11 (0.069 g, 0.163 mmol) and 4-(2-aminoethyl)morpholine (0.107 ml, 0.815 mmol) were dissolved in DMSO (0.03 ml) and heated at 80° C. for 26 h in a sealed vial (eg Reacti vial™), a further portion of 4-(2-aminoethyl)morpholine (0.053 ml, 0.407 mmol) was added after the first 20 h. The product was purified by Autoprep. HPLC to give the title compournd after freeze drying as a brown solid (0.059 g). LC/MS system B Rt=2.19 min, m/z=517MH+.

情報源と証拠