Dimethyl Sulfoxide → (2S,3S,4R,5R)-2-(3-Ethyl-[1,2,4]oxadiazol-5-yl)-5-(6-(1-ethyl-propylamino)-2-[2-(1-methyl-1H-imidazol-4-yl)-ethylamino]-purin-9-yl}tetrahydro-furan-3,4-diol formate

참여 물질

역할	이름	HCID	투입량
반응물	Dimethyl Sulfoxide	HCID 679	—
반응물	1-Methylhistamine	HCID 3614	—
반응물	(2r,3r,4s,5s)-2-[2-Chloro-6-(1-ethyl-propylamino)-purin-9-yl]-5-(3-ethyl-[1,2,4]oxadiazol-5-yl)-tetrahydro-furan-3,4-diol	HCID 56625647	—
생성물	(2S,3S,4R,5R)-2-(3-Ethyl-[1,2,4]oxadiazol-5-yl)-5-(6-(1-ethyl-propylamino)-2-[2-(1-methyl-1H-imidazol-4-yl)-ethylamino]-purin-9-yl}tetrahydro-furan-3,4-diol formate	HCID 70020463	—

반응 조건

온도	92.5 °C

반응 단계

Intermediate 9 (0.070 g, 0.161 mmol) and 2-(1-methyl-1H-imidazol-4-yl)ethylamine (0.101 g, 0.807 mmol) were dissolved in DMSO (0.03 ml) and heated at 85-100° C. under nitrogen for 8 days, a further portion of 2-(1-methyl-1H-imidazol-4-yl)ethylamine (0.101 g, 0.807 mmol) was added after the first 5 days. The product was purified by Autoprep. HPLC to give the title compound after freeze drying as a cream solid (0.010 g). LC/MS system A Rt=3.36 min, m/z=526 MH+.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06610665B1
출처 데이터셋	uspto-grants-2003_08
ORD ID	ord-34d6f7ebeb87493e9b38bbb5999c2276
출처 메모	uspto-grants-2003_08