Dimethyl Sulfoxide → (2r,3r,4s,5s)-2-[6-(1-Ethyl-propylamino)-2-(2-piperidin-1-yl-ethylamino)-purin-9-yl]-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-tetrahydro-furan-3,4-diol formate

Participants

Reaction Steps

Intermediate 11 (0.069 g, 0.163 mmol) and 2-piperidinoethylamine (0.116 ml, 0.815 mmol) were dissolved in DMSO (0.03 ml) and heated at 80° C. for 40 h in a sealed vial (Reacti vial™) a further portion of 2-piperidinoethylamine (0.058 ml, 0.407 mmol) was added after the first 20 h. The product was purified by Autoprep. HPLC to give the title compound after freeze drying as a brown solid (0.031 g). LC/MS system B Rt=2.25 min, m/z=516 MH+.

Provenance & Evidence