1-Hydroxybenzotriazole → HCID 23001315, compound

Participants

Reaction Steps

Carboxylic acid from Step K, Example 5 (13.4 mg, 0.0496 mmol), amine from Step D (20.0 mg, 0.0496 mmol), EDC hydrochloride (19.0 mg, 0.0991 mmol), HOBT (13.4 mg, 0.0991 mmol), and N,N-diisopropylethylamine (0.0432 mL, 0.248 mmol) were stirred in dry, degassed DMF (1 mL) at 25° C. for 16 hours. The reaction was poured onto aq. NaHCO3 (10 mL) and extracted with methylene chloride (3×10 mL). The combined organic layers were dried (Na2SO4), filtered, and concentrated in vacuo to provide the title compound as a white solid.

Provenance & Evidence