HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → Di-tert-butyl ether
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Reactant | N,N'-dimethyl-O-t-butylisourea | HCID 23001675 | — |
| Product | Di-tert-butyl ether | HCID 22541 | 15% |
Reaction Steps
Following a procedure analogous to (3b), the phenol from (3a) (270 mg, 0.97 mmol) was reacted with N,N′-dimethyl-O-t-butylisourea. Silica gel chromatography (ethyl acetate-hexane, 20:80) gave the t-butyl ether (50.2 mg, 15%) as a 1:1 mixture of two isomers. MS found: (M+H)+=334.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06610731B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-06a1d31e4388451ab0e3ab6eef91a634 |
| Source note | uspto-grants-2003_08 |