Ethanol → HCID 54112706, compound

Participants

Reaction Steps

Conc. sulfuric acid (2.2 ml) was added carefully to a suspension of 2-(4-fluorophenyl)-3-(4-pyridyl)-acrylic acid (6.7 g, 27.5 mmol) in ethanol (120 ml) and the mixture was heated at reflux for 24 h. The solvent was evaporated, the remainder was taken up in dichloromethane and the organic solution was washed with aqueous sodium hydrogencarbonate and water, followed by drying and evaporation. Flash column chromatography on silica gel (hexane-acetone=2:1) provided the pure title compound. MS (m/z): 271.8 (M+H)+; C16H14FNO2 requir. 271.3 1H-NMR (CDCl3): 8.44, 6.88 (2 m, each 2H, Pyrid.), 7.72 (s, 1H, CH═), 7.16, 7.06 (2 m, each 2H, PhF), 4.28 (q, 2H, CH2), 1.28 (t, 3H, CH3).

Provenance & Evidence