Acetic Anhydride → HCID 54521091, compound

HRID 398034Notes

Reaction equation

HRID 398034 reaction equation
[NH2:1][C@@H:2]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:3][NH:4][C:5]1[N:10]([CH3:11])[C:9](=[O:12])[C:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[C:7]([C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)[N:6]=1.[C:33](OC(=O)C)(=[O:35])[CH3:34]>CO>[C:33]([NH:1][C@@H:2]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:3][NH:4][C:5]1[N:10]([CH3:11])[C:9](=[O:12])[C:8]([C:13]2[CH:14]=[CH:15][C:16]([F:19])=[CH:17][CH:18]=2)=[C:7]([C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)[N:6]=1)(=[O:35])[CH3:34]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 15463810HCID 15463810, compound

Product 1

HCID 54521091HCID 54521091, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2-(((S)-2-amino-3-phenylpropyl)-amino)-5-(4-fluorophenyl)-3-methyl-6-(4-pyridyl)-4(3H)-pyrimidinone (25 mg, 0.058 mmol) and acetic anhydride (200 ml) in methanol (2 ml) was kept at room temperature for 1 h. Evaporation followed by chromatography of the resultant product on a column of silica gel (10% methanol/dichloromethane) provided the title compound.

Workup

  1. customEvaporation

Sources & evidence

ORD record
ord-ba34a4ee50de434ab71175d7f5d3be3d
Source dataset
uspto-grants-2003_08
Patent number
US06610698B2

Reaction notes

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