Methanol → HCID 18767998, compound

HRID 398044Notes

Reaction equation

HRID 398044 reaction equation
[CH2:1]([N:3]1[C:8](=[O:9])[C:7]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[C:6]([C:17]2[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=2)[N:5]=[C:4]1[S:23][CH3:24])[CH3:2].OOS([O-])=O.[K+].S([O-])(O[O-])(=O)=O.[K+].[K+].[OH2:39].C[OH:41]>>[CH2:1]([N:3]1[C:8](=[O:9])[C:7]([C:10]2[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=2)=[C:6]([C:17]2[CH:18]=[CH:19][N:20]=[CH:21][CH:22]=2)[N:5]=[C:4]1[S:23]([CH3:24])(=[O:41])=[O:39])[CH3:2]

Participants

6

Reactant 5

HCID 887MethanolHCID 962WaterHCID 10313463Potassium peroxymonosulphateHCID 18767913HCID 18767913, compoundHCID 23707502Potassium hydroxy sulfite

Product 1

HCID 18767998HCID 18767998, compound

Procedure

A mixture of 3-ethyl-5-(4-fluorophenyl)-2-methylthio-6-(4-pyridyl)-4(3H)-pyrimidinone (300 mg, 0.88 mmol) and Oxone® (potassium peroxymonosulfate, 2.54 g, 4.14 mmol) in methanol (71 ml) and water (33 ml) was stirred for 14 h. The solvent was concentrated to about 35 ml, followed by extraction with dichloromethane, drying and evaporation. The resulting white solid was used without purification in the next step.

Workup

  1. concentrationThe solvent was concentrated to about 35 ml
  2. extractionfollowed by extraction with dichloromethane
  3. customdrying
  4. customevaporation
  5. customThe resulting white solid was used without purification in the next step

Sources & evidence

ORD record
ord-ce8917683f514eb1ae7bd1fd37fc6ccb
Source dataset
uspto-grants-2003_08
Patent number
US06610698B2

Reaction notes

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