HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine chloride → 8Iodo-2,2,4,4-tetramethy-6-chromanoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine chloride | HCID 24640 | — |
| Reactant | 2,2,4,4-Tetramethyl-3,4-dihydro-2H-1-benzopyran-6-carboxylic acid | HCID 15728709 | — |
| Reactant | 8-Bromo-2,2,4,4-tetramethyl-6-chromanoic acid | HCID 15840535 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 8Iodo-2,2,4,4-tetramethy-6-chromanoic Acid | HCID 23001763 | 106.1% |
Reaction Steps
To a solution of 2,2,4,4-tetramethyl-6-chromanoic acid (66 mg, 0.28 mmol) in 0.8 ml of AcOH was added ICl (0.07 ml, 1.4 mmol). The resulting colored solution was stirred at room temperature for overnight. Following the same procedure as for the synthesis of 8-bromo-2,2,4,4-tetramethyl-6-chromanoic acid (Compound P), the reaction gave the title compound (107 mg) as white solids.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06610744B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-4373544e45264bb59b9adcb73541a31d |
| Source note | uspto-grants-2003_08 |