Nitric Acid → HCID 23001766, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 2,2,4,4-tetramethyl-6-chromanoate (150 mg, 0.57 mmol) was slowly added to 0.3 ml of conc. H2SO4 at 0° C. To this mixture was added very slowly 0.03 ml of HNO3. The reaction mixture was stirred at 0° C. for 30 min and poured into ice-water. The product was extracted into 5 ml of ethyl acetate, washed with NaHCO3 (sat.), brine and dried over MgSO4. After concentration, the product was purified by column chromatography (ethyl acetate/hexane 1/10) to yield 74 mg of light-yellow oil.

Provenance & Evidence