8-Bromo-2,2,4,4-tetramethyl-6-chromanoic acid → 8-Bromo-4,4-dimethyl-6-chromanoic Acid

HRID 398061Notes

Reaction equation

HRID 398061 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:16]([OH:18])=[O:17])[CH:5]=[C:6]2[C:11]=1[O:10][C:9](C)(C)[CH2:8][C:7]2([CH3:15])[CH3:14].CC1(C)C2C(=CC=CC=2)OC(C(O)=O)C1>>[Br:1][C:2]1[CH:3]=[C:4]([C:16]([OH:18])=[O:17])[CH:5]=[C:6]2[C:11]=1[O:10][CH2:9][CH2:8][C:7]2([CH3:14])[CH3:15]

Participants

3

Reactant 2

HCID 158405358-Bromo-2,2,4,4-tetramethyl-6-chromanoic acid2×HCID 230017694,4-Dimethylchromanoic acid

Product 1

HCID 158405348-Bromo-4,4-dimethyl-6-chromanoic Acid

Procedure

Using the same procedure as for the synthesis of 8-bromo-2,2,4,4-tetramethylchromanoic acid (Compound P) but using 4,4-dimethylchromanoic acid (100 mg, 0.49 mmol), the title compound was obtained as a white solid.

Sources & evidence

ORD record
ord-cdcd6ac140e341a892ddc8dd40799631
Source dataset
uspto-grants-2003_08
Patent number
US06610744B2

Reaction notes

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