Hydrogen chloride-ethyl acetate → HCID 131730109, compound

HRID 39811Notes

Reaction equation

HRID 39811 reaction equation
O1C2C=CC(CN(C3CCN(CC[N:28]4[C:37]5[C:32](=[CH:33][CH:34]=[C:35]([O:38][CH3:39])[CH:36]=5)[CH:31]=[CH:30][C:29]4=[O:40])CC3)C(=O)OC(C)(C)C)=CC=2OCC1.[ClH:41].C(OCC)(=O)C>>[ClH:41].[CH3:39][O:38][C:35]1[CH:36]=[C:37]2[C:32]([CH:31]=[CH:30][C:29](=[O:40])[NH:28]2)=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59398114HCID 59398114, compound

Product 1

HCID 131730109HCID 131730109, compound

Procedure

0.29 g of tert-butyl (2,3-dihydro-1,4-benzodioxin-6-ylmethyl)(1-(2-(7-methoxy-2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate was added to 10 mL of 4 mol/L hydrogen chloride/ethyl acetate solution, and stirred at room temperature for 22 hours. The solvent was removed under reduced pressure, 2-propanol was added to the residue obtained and the resulting solid was filtered to afford 0.20 g of 1-(2-(4-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-7-methoxyquinolin-2(1H)one hydrochloride as a pale yellowish white solid.

Workup

  1. customThe solvent was removed under reduced pressure, 2-propanol
  2. additionwas added to the residue
  3. customobtained
  4. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-438802cf5a834547ada30773a7f23f7d
Source dataset
uspto-grants-2013_09
Patent number
US08524738B2

Reaction notes

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