HCID 22633457, compound → HCID 22633440, compound

HRID 398157Notes

Reaction equation

HRID 398157 reaction equation
C([O:8][C:9]1[CH:35]=[CH:34][C:12]([O:13][CH2:14][CH2:15][C:16]2[N:17]=[C:18]([C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)=[CH:24][CH:23]=3)[O:19][C:20]=2[CH3:21])=[C:11]([CH2:36][CH2:37][CH2:38][CH3:39])[CH:10]=1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[CH2:36]([C:11]1[CH:10]=[C:9]([OH:8])[CH:35]=[CH:34][C:12]=1[O:13][CH2:14][CH2:15][C:16]1[N:17]=[C:18]([C:22]2[CH:23]=[CH:24][C:25]([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)=[CH:26][CH:27]=2)[O:19][C:20]=1[CH3:21])[CH2:37][CH2:38][CH3:39]

Participants

5

Reactant 2

HCID 22633457HCID 22633457, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22633440HCID 22633440, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 4-[2-(4-benzyloxy-2-butylphenoxy)ethyl]-5-methyl-2-biphenyl-4-yl-oxazole (3.16 mmol) in ethanol (100 mL) was treated with 5% Pd/C (160 mg) and hydrogen (60 psi) at ambient temperature for 18 h. The mixture was filtered and concentrated in vacuo to give 3-butyl-4-[2-(5-methyl-2-biphenyl-4-yl-oxazole-4-yl)ethoxy]phenol as a tan solid.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-e3d1b39385bd404ca9f63fc51831e8e6
Source dataset
uspto-grants-2003_08
Patent number
US06610696B2

Reaction notes

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