HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Azide → 2-azido-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 2-chloro-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide | HCID 11357806 | — |
| Product | 2-azido-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide | HCID 11594330 | — |
Reaction Steps
The synthesis of Midodrine HCl consists of reacting the key intermediate (2) with chloroacetyl chloride to afford 2-chloro-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide (3). The reaction of (3) with sodium azide will provide 2-azido-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide (4) which is subsequently subjected to hydrogenation to afford Midodrine base (6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06610886B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-be5fb5e3691e4d648c52f8812a3a70c2 |
| Source note | uspto-grants-2003_08 |