HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-3-phenylbutanoic acid → 5-chloro-N-[(1S)-1-cyclohexyl-2-hydroxyethyl]thiophene-2-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-3-phenylbutanoic acid | HCID 64808 | — |
| Reactant | Alloisoleucine, DL- | HCID 99288 | — |
| Reactant | (alphaS)-alpha-Aminocyclohexaneacetic acid | HCID 736848 | — |
| Reactant | 5-Bromothiophene-2-sulfonyl chloride | HCID 2733924 | — |
| Reactant | 5-Chlorothiophene-2-sulfonyl chloride | HCID 2733925 | — |
| Product | 5-chloro-N-[(1S)-1-cyclohexyl-2-hydroxyethyl]thiophene-2-sulfonamide | HCID 12987475 | — |
Reaction Steps
The following compounds (Examples 12-17, Table 4) were prepared using 5-chlorothiophene-2-sulfonyl chloride, and 5-bromothiophene-2-sulfonyl chloride with L-cyclohexylglycine, β-methyl-DL-phenylalanine, and L-allo-isoleucine and following the procedure outlined in Example 12.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06610734B2 |
| Source dataset | uspto-grants-2003_08 |
| ORD ID | ord-10fc2f331d494ab98626452552a212b1 |
| Source note | uspto-grants-2003_08 |