Diisopropylethylamine → HCID 9856569, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-thiophenesulfonyl chloride (1 g, 5.48 mmol) in CH2Cl2 (5 mL) and (S)-isoleucinol (642 mg, 5.48 mmol) was added Hunig's base (1. 05 mL, 6.02 mmol). The reaction mixture was stirred at 25° C. for 24 h. The solvent was removed and the oil was dissolved in EtOAc (100 mL). The solution was washed with water (2×100 mL), brine (1×100 mL), and dried over Na2SO4. The desired sulfonamide (m/z=264.0(M+H), rt=0.79 min) was isolated by semi-preparative RP-HPLC using the conditions outlined for example 195.

Provenance & Evidence