3-ethyl-N2-[(S)-1-phenylethyl]-L-norvalinamide → 3-ethyl-L-norvalinamide

HRID 398294Notes

Reaction equation

HRID 398294 reaction equation
[CH2:1]([CH:3]([CH2:17][CH3:18])[C@@H:4]([C:14]([NH2:16])=[O:15])[NH:5][C@H](C1C=CC=CC=1)C)[CH3:2]>[Pd]>[CH2:1]([CH:3]([CH2:17][CH3:18])[C@@H:4]([C:14]([NH2:16])=[O:15])[NH2:5])[CH3:2]

Participants

3

Reactant 1

HCID 669301253-ethyl-N2-[(S)-1-phenylethyl]-L-norvalinamide

Product 1

HCID 116439453-ethyl-L-norvalinamideYield 93%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of 3-ethyl-N2-[(S)-1-phenylethyl]-L-norvalinamide (2.6 g, 10.5 mmol) and 5% Pd/C. (800 mg) was shaken for 24 h in a Parr apparatus under 3 atm of H2. The mixture was filtered through a plug of Celite and the solvent was removed in vacuo to give 3-ethyl-L-norvalinamide as a white solid (1.4 g, 93%), which was used in the next reaction without further purification. Mass Spectrum (+ESI): 145 (M+H)+.

Workup

  1. filtrationThe mixture was filtered through a plug of Celite
  2. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-637b61d585de4037a2bf58eb866a074d
Source dataset
uspto-grants-2003_08
Patent number
US06610734B2

Reaction notes

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