Triethylamine → HCID 23000157, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloropyrimidine (4.0 g, 35 mmol), 5-aminopent-2-yne (10.5 g, 88 mmol), triethylamine (12.3 mL, 88 mmol) in ethanol (50 mL) was heated in a sealed tube at 90° C. for 16 h. The mixture was cooled and evaporated in vaciio. The residue was taken up in ethyl acetate and was filtered through a plug of silica gel, eluting with ethyl acetate, and evaporated in vacuo to give the title compound:

Provenance & Evidence