Potassium Hydroxide → 4-Methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine

Participants

Reaction Conditions

Reaction Steps

Potassium hydroxide (1 M, 5 mL) was added to a stirred solution of N-acetyl-4-methyl-7-azaindoline (0.78 g, 4.75 mmol) in methanol (10 mL) and the resulting mixture was heated to 55° C. for 4 h. The mixture was cooled and partitioned between methylene chloride and dilute ammonium hydroxide solution. The organic layer was dried (Na2SO4) and evaporated in vacuo to give the title compound as a yellow solid:

Provenance & Evidence