Triethylamine → 3-amino-1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	Hydrazine hydrate (1:1)	HCID 24654	—
Reactant	2-Chloropyridine-3,5-dicarbonitrile	HCID 10986579	—
Solvent	Ethanol	HCID 702	—
Product	3-amino-1H-Pyrazolo[3,4-b]pyridine-5-carbonitrile	HCID 178510334	—

Reaction Conditions

Temperature	60 °C

Reaction Steps

Hydrazine hydrate (55%, 125 mL, 2.20 mmol) was added to a stirred suspension of 2-chloro-3,5-dicyanopyridine (240 mg, 1.47 mmol) and triethylamine (205 μL, 1.47 mmol) in ethanol (3 mL) and the resulting red mixture was heated to 60° C. After 16 h the mixture was cooled and filtered to give the title compound:

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06610692B1
Source dataset	uspto-grants-2003_08
ORD ID	ord-fb4f728e33fb4941921077b54130ea1b
Source note	uspto-grants-2003_08