Chlorosuccinimide → HCID 54477116, compound

Participants

Reaction Steps

To a solution of 5-(t-butoxycarbonylaminomethyl)-indole (0.51 g, 2.05 mmol) in CH2Cl2, (12 mL) under Argon at 15°-20° C. was added N-chlorosuccinimide (0.245 g, 1.82 mmol) portionwise over 1 hr. The reaction stirred 0.5 h and was partitioned with H2O and CH2Cl2. The aquesous layer was extracted with CH2Cl2 (2×), dried over MgSO4, filtered, and concentrated in vacuo to a brown residue. Purification via flash chromatography (25×150 mm column; gradient elution with EtOAc: hexanes, 1:4 to 1:3) yielded a colorless oil:

Provenance & Evidence