Dimethylformamide → HCID 23000187, compound

Participants

Reaction Steps

To a stirred solution of 3-benzyloxy-4-carboxy-6-methyl-1-tert-butyloxycarbonylmethyl-2-pyridinone from step 3 above (0.91 g, 2.3 mmol) in DMF (6 mL) was added dilsobutylamine (0.48 mL, 2.8 mmol), HATU (1.76 g, 4.6 mmol), and DIEA (0.45 mL, 2.6 mmol). The resulting solution was stirred at ambient temperature for 18 h. The solvents were removed in vacuo and the residue was purified by flash column chromatography using a gradient elution of 25-50% EtOAc:hexanes to give the title compound as an oil (0.80 g; HPLC RT 24.80 min, method B).

Provenance & Evidence