Sodium Hydroxide → 3-Acetyl-4-(2-isopropylphenyl)-6-methyl-1-carboxymethyl-2-pyridinone

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Reaction Steps

To a stirred solution of 3-acetyl-4-(2-isopropylphenyl)-6-methyl-1-ethoxycarbonylmethyl-2-pyridinone from step 3 of Example XX (0.20 g, 0.56 mmol) in ethanol (4 mL) was added aqueous NaOH (0.62 mL of a 1.0 N solution, 0.62 mmol). The resulting solution was stirred at ambient temperature for 2 h and the solvent was removed in vacuo. The residue was partitioned between EtOAc and 1.0 N aqueous HCl. The organic phase was separated and the aqueous phase was extracted with EtOAc. The combined organic extracts were dried over Na2SO4, filtered, and concentrated in vacuo to give the title compound (HPLC RT=18.11 min, method B).

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