Hydrochloric Acid → 3-Hydroxy-4-(2-isopropylphenyl)-6-methyl-1-carboxymethyl-2-pridinone

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Reaction Steps

To a stirred solution of 3-acetoxy-4-(2-isopropylphenyl)-6-methyl-1-ethoxycarbonylmethyl-2-pyridinone from step 4 above (0.325 g, 0.95 mmol) in ethanol (4 mL) was added aqueous NaOH (2.2 mL of a 1.0 N solution, 2.2 mmol). The resulting solution was stirred at ambient temperature for 18 h. The solution was acidified with aqueous HCl (2.2 mL of a 1.0 N solution, 2.2 mmol) and the solvents were removed in vacuo to give the title compound as an amorphous solid containing NaCl (HPLC RT=18.67 min, method B).

Provenance & Evidence