HCID 53831436, compound → HCID 70023589, compound

Participants

Reaction Steps

A mixture of 4-phenylethynyl-6-methyl-1-ethoxycarbonylmethyl-2-pyridinone from step 3 above (1.5 g, 4.6 mmol) and Lindlar catalyst (5%Pd on CaCO3 plus Pb;150 mg) in EtOH (25 mL) was stirred under an atmosphere of hydrogen at ambient pressure and temperatue for 1 h. The catalyst was removed by filtration and the filtrate solvent was removed in vacuo to give the title compound as a mixture containing 20% of the fully saturated (phenethyl) derivative (1.5 g; TLC Rf=0.5, 1:1 EtOAc:hexanes; HPLC RT=8.15 min, method A).

Provenance & Evidence