Isobutylene oxide → Ammonium Hydroxide

Participants

Reaction Steps

A solution of 4-(cis-3-phenylpyrrolidin-4-yl)-6-methyl-1-ethoxycarbonylmethyl-2-pyridinone from step 6 above (0.2 g, 0.54 mmol) and isobutylene oxide (1 mL) in EtOH (4 mL) was heated to reflux for 1 h. The solvent was removed in vacuo and the residue was purified by flash column chromatography using 96:4:0.2 CH2Cl2:MeOH:NH4OH as eluant to give the title compound as an oil (0.17 g; TLC Rf=0.3, 96:4:0.2 CH2Cl2:MeOH:NH4OH; HPLC RT=5.08 min, method A).

Provenance & Evidence