Hydrochloric Acid → HCID 12096228, compound

Participants

Reaction Steps

A solution of 4-(1-(2-hydroxy-2-methylpropyl)-cis-3-phenylpyrrolidin-4-yl)-6-methyl-1-ethoxycarbonylmethyl-2-pyridinone from step 7 above (0.10 g, 0.23 mmol) and aqueous NaOH (0.11 mL of a 4.0N solution, 0.46 mmol) was stirred at ambient temperature for 18 h. Aqueous HCl was added (0.076 mL of a 6.0 N solution, 0.46 mmol) and the solvents were removed in vacuo to give the title compound as an amorphous solid mixed with NaCl (HPLC RT=3.94 min, method A).

Provenance & Evidence