1-Tert-butyloxycarbonyl-trans-3-benzyloxycarbonylamino-4-(2-pyridyl)pyrrolidine → 1-Tert-butyloxycarbonyl-trans-3-amino-4-(2-pyridyl)pyrrolidine

Participants

Reaction Steps

To a solution of 1-tert-butyloxycarbonyl-trans-3-benzyloxycarbonylamino-4-(2-pyridyl)pyrrolidine from step 6 above (3.9 g, 9.8 mmol) in EtOH (25 mL) was added 10% Pd on carbon (1.5 g). The mixture was shaken under an atmosphere of hydrogen (40 psi) at ambient temperature for 18 h on a Parr apparatus. The catalyst was removed by filtration and the solvent was removed in vacuo to give the title compound as an oil (2.5 g, HPLC RT=3.96 min, method A).

Provenance & Evidence