Hydrochloric Acid → HCID 59398254, Verbindung

HRID 39859Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 39859
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][C:9](=[O:16])[N:10]2[CH2:13][CH:14]=O)=[CH:5][CH:4]=1.Cl.[O:18]1[C:23]2[CH:24]=[CH:25][C:26]([CH2:28][NH:29][CH:30]3[CH2:35][CH2:34][NH:33][CH2:32][CH:31]3[C:36]([O:38][CH3:39])=[O:37])=[CH:27][C:22]=2[O:21][CH2:20][CH2:19]1.Cl>O1CCOCC1>[O:18]1[C:23]2[CH:24]=[CH:25][C:26]([CH2:28][NH:29][CH:30]3[CH2:35][CH2:34][N:33]([CH2:14][CH2:13][N:10]4[C:11]5[C:6](=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:12]=5)[CH:7]=[CH:8][C:9]4=[O:16])[CH2:32][CH:31]3[C:36]([O:38][CH3:39])=[O:37])=[CH:27][C:22]=2[O:21][CH2:20][CH2:19]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 59397833(7-methoxy-2-oxoquinolin-1(2H)-yl)acetaldehydeHCID 67539408HCID 67539408, Verbindung

Produkt 1

HCID 59398254HCID 59398254, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

As similarly to Example 1, to 0.10 g of methyl 4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)-1-(2-(7-methoxy-2-oxoquinolin-1(2H)-yl)ethyl)piperidine-3-carboxylate obtained from (7-methoxy-2-oxoquinolin-1(2H)-yl)acetaldehyde and methyl 4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidine-3-carboxylate hydrochloride, 1.0 mL of 6 mol/L hydrochloric acid and 1.0 mL of dioxane were added. The reaction mixture was stirred under reflux with heating for 3 hours. The solvent was removed, acetonitrile was added, and resulting solid was filtered to afford 54 mg of 4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)-1-(2-(7-methoxy-2-oxoquinolin-1(2H)-yl)ethyl)piperidine-3-carboxylic acid hydrochloride as a brown solid.

Quellen und Nachweise

ORD-Eintrag
ord-9d0d14856f7240aea9755a576a57d68a
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524738B2

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