Hydrogen chloride-ethyl acetate → HCID 67539031, compound

Participants

Reaction Steps

To 5 mL of an ethyl acetate solution containing 369 mg of tert-butyl (2,3-dihydro-1,4-benzodioxin-6-ylmethyl)(1-(2-(7-methoxy-5-((methylamino)carbonyl)-2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate, 9 mL of 4 mol/L hydrogen chloride/ethyl acetate was added and stirred at room temperature for 2 hours. The solvent was removed under reduced pressure, ethyl acetate was added to the residue thus obtained, and the resulting solid was filtered to give 205 mg of 1-(2-(4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-7-methoxy-N-methyl-2-oxo-1,2-dihydroquinoline-5-carboxamide hydrochloride as a white solid.

Provenance & Evidence