Ethanol → HCID 86753190, compound

Participants

Reaction Steps

A solution of (+/-)-trans 3-carboxymethyl-2-(3,4-methylenedioxyphenyl)-2,3dihydro[1,5]benzothiazepine-4(5H)-one (0.050 g, 0.14 mmole) in EtOH (3 ml) was treated with 25% NaOH (0.5 ml) under argon. The mixture was stirred 18 hours, and then the solvent was evaporated. H2O (3 ml) was added to the residue and the mixture acidified to pH 1 with 10% HCl. The mixture was stirred for 0.5 hours and the crystallized product was collected, washed with H2O (3 ml) and dried to give the tide compound (0.032 g, 67%) as a light yellow solid, mp 110° C.

Provenance & Evidence