Dimethylamine → HCID 54280578, compound

HRID 398803Notes

Reaction equation

HRID 398803 reaction equation
[CH3:1][NH:2][CH3:3].[Cl:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:15](=[O:16])[C:14]3[CH2:17][CH2:18][CH2:19][CH2:20][C:13]=3[C:12]2=[O:21])=[CH:7][C:6]=1[CH:22]=[C:23]([Cl:29])[C:24]([O:26][CH2:27][CH3:28])=[O:25]>C(#N)C>[CH3:1][N:2]([CH3:3])[C:15](=[O:16])[C:14]1[CH2:17][CH2:18][CH2:19][CH2:20][C:13]=1[C:12]([NH:11][C:8]1[CH:9]=[CH:10][C:5]([Cl:4])=[C:6]([CH:22]=[C:23]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[Cl:29])[CH:7]=1)=[O:21]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 3525006Ethyl 2-chloro-3-(2-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)phenyl)-2-propenoate

Product 1

HCID 54280578HCID 54280578, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

1.39 ml of a 40% strength by weight aqueous dimethylamine solution were added to a solution of 3.9 g of N-[4-chloro-3-(2-chloro-2-ethoxycarbonylethenyl)phenyl]-3,4,5,6-tetrahydrophthalimide in 100 ml of acetonitrile at about 20° C. The mixture obtained was stirred for a further 20 hours at 20°-25° C., after which the solid formed was separated off, washed with petroleum ether and finally dried. Mp.: 161°-164° C.

Workup

  1. customThe mixture obtained
  2. customafter which the solid formed
  3. customwas separated off
  4. washwashed with petroleum ether
  5. customfinally dried

Sources & evidence

ORD record
ord-3d7dfb7ca59b4be4aa46cc3576aafbbf
Source dataset
uspto-grants-1998_10
Patent number
US05817603

Reaction notes

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