Acetic Anhydride → HCID 18969175, compound

Participants

Reaction Steps

Acetic anhydride (40 ml) solution containing 3-(3-chlorobenzoyl)-2-methylaminopyridine (3.16 g, 13 mmol) was heated under reflux for 4 hours. The reaction solution was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (benzene-ethyl acetate) to give N-[3-(3-chlorobenzoyl)-2-pyridyl]-N-methylacetamide (3.34 g, 90%).

Provenance & Evidence