Butyryl chloride → HCID 11044798, compound

HRID 398860Notes

Reaction equation

HRID 398860 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1.[C:18](Cl)(=[O:22])[CH2:19][CH2:20][CH3:21]>>[C:18]([NH:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1)(=[O:22])[CH2:19][CH2:20][CH3:21]

Participants

3

Reactant 2

HCID 8855Butyryl chlorideHCID 102202303-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ylamine

Product 1

HCID 11044798HCID 11044798, compoundYield 56.3%

Procedure

Beginning with 0.30 gm (1.3 mMol) 5-amino-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine and 0.165 mL (1.56 mMol) butyryl chloride, 0.22 gm of the title compound were prepared as an ivory foam essentially by the procedure described in Example 4. This residue was crystallized from ethanol:water to provide material for analysis.

Sources & evidence

ORD record
ord-6e1bc8314a774467bad458c69e0309f8
Source dataset
uspto-grants-1998_10
Patent number
US05817671

Reaction notes

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