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5-Methylthiophene-2-carbonyl chloride → 5-(N-[5-methyl-2-thiophenecarbonyl]amino)-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Methylthiophene-2-carbonyl chloride | HCID 2760083 | — |
| 反応物 | 3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ylamine | HCID 10220230 | — |
| 生成物 | 5-(N-[5-methyl-2-thiophenecarbonyl]amino)-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine | HCID 19601511 | 86% |
反応手順
Beginning with 0.40 gm (1.74 mMol) 5-amino-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine and 0.34 gm (2.08 mMol) 5-methyl-2-thiophenecarbonyl chloride, 0.53 gm (86%) of the title compound were prepared essentially by the procedure described in Example 4.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05817671 |
| 出典データセット | uspto-grants-1998_10 |
| ORD ID | ord-5834741049f14747bdb66606ef405bd3 |
| 出典メモ | uspto-grants-1998_10 |