3-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ylamine → HCID 19601508, compound

HRID 398912Notes

Reaction equation

HRID 398912 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1.[CH3:18][C:19]1[S:20][C:21]([CH3:27])=[C:22]([C:24](Cl)=[O:25])[N:23]=1>>[CH3:18][C:19]1[S:20][C:21]([CH3:27])=[C:22]([C:24]([NH:1][C:2]2[N:7]=[C:6]3[C:8]([CH:11]4[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]4)=[CH:9][NH:10][C:5]3=[CH:4][CH:3]=2)=[O:25])[N:23]=1

Participants

3

Reactant 2

HCID 102202303-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ylamineHCID 19601484HCID 19601484, compound

Product 1

HCID 19601508HCID 19601508, compound

Procedure

Beginning with 0.34 gm (1.6 mMol) 5-amino-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine and 0.44 gm (2.50 mMol) 2,5-dimethyl-4-thiazolecarbonyl chloride, the title compound was prepared essentially by the procedure described in Example 4.

Sources & evidence

ORD record
ord-2eea7efc1bfe4c858b1a0e0c156aecd3
Source dataset
uspto-grants-1998_10
Patent number
US05817671

Reaction notes

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