2-Chloronicotinoyl chloride → HCID 19601586, compound

HRID 398914Notes

Reaction equation

HRID 398914 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1.[Cl:18][C:19]1[C:24]([C:25](Cl)=[O:26])=[CH:23][CH:22]=[CH:21][N:20]=1>>[Cl:18][C:19]1[C:24]([C:25]([NH:1][C:2]2[N:7]=[C:6]3[C:8]([CH:11]4[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]4)=[CH:9][NH:10][C:5]3=[CH:4][CH:3]=2)=[O:26])=[CH:23][CH:22]=[CH:21][N:20]=1

Participants

3

Reactant 2

HCID 27745412-Chloronicotinoyl chlorideHCID 102202303-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ylamine

Product 1

HCID 19601586HCID 19601586, compound

Procedure

Beginning with 0.010 gm (0.044 mMol) 5-amino-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine and 0.054 mMol 2-chloro-3-pyridinecarbonyl chloride, the title compound was prepared essentially by the procedure described in Example 7.

Sources & evidence

ORD record
ord-a2691943366b4ba9815ca7909ca3161a
Source dataset
uspto-grants-1998_10
Patent number
US05817671

Reaction notes

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