Butanoic acid, 4-chloro-4-oxo-, methyl ester → HCID 19601584, compound

HRID 398917Notes

Reaction equation

HRID 398917 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1.[CH3:18][O:19][C:20]([CH2:22][CH2:23][C:24](Cl)=[O:25])=[O:21]>>[CH3:18][O:19][C:20]([CH2:22][CH2:23][C:24]([NH:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1)=[O:25])=[O:21]

Participants

3

Reactant 2

HCID 73888Butanoic acid, 4-chloro-4-oxo-, methyl esterHCID 102202303-(1-Methyl-piperidin-4-yl)-1H-pyrrolo[3,2-b]pyridin-5-ylamine

Product 1

HCID 19601584HCID 19601584, compoundYield 67%

Procedure

Beginning with 0.010 gm (0.044 mMol) 5-amino-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-b]pyridine and 0.007 mL (0.057 mMol) 3-methoxycarbonylpropionyl chloride, 0.01 gm (67%) of the title compound were prepared essentially by the procedure described in Example 7.

Sources & evidence

ORD record
ord-a47bf5fcbfd641f297d0b8f8eb211c3c
Source dataset
uspto-grants-1998_10
Patent number
US05817671

Reaction notes

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