3-Furoyl chloride → 5-(N-[3-furoyl]amino)-3-(ethylpiperidin-4-yl)pyrrolo[3,2-b]pyridine

HRID 398933Notes

Reaction equation

HRID 398933 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH3:18])[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1.[O:19]1[CH:23]=[CH:22][C:21]([C:24](Cl)=[O:25])=[CH:20]1>>[O:19]1[CH:23]=[CH:22][C:21]([C:24]([NH:1][C:2]2[N:7]=[C:6]3[C:8]([CH:11]4[CH2:16][CH2:15][N:14]([CH2:17][CH3:18])[CH2:13][CH2:12]4)=[CH:9][NH:10][C:5]3=[CH:4][CH:3]=2)=[O:25])=[CH:20]1

Participants

3

Reactant 2

HCID 27761233-Furoyl chlorideHCID 117706865-Amino-3-(1-ethylpiperidin-4-yl)pyrrolo[3,2-b]pyridine

Product 1

HCID 196014685-(N-[3-furoyl]amino)-3-(ethylpiperidin-4-yl)pyrrolo[3,2-b]pyridine

Procedure

Beginning with 0.015 gm (0.061 mMol) 5-amino-3-(1-ethylpiperidin-4-yl)pyrrolo[3,2-b]pyridine and 0.010 mL (0.080 mMol) 3-furoyl chloride, the title compound was prepared essentially by the procedure described in Example 7.

Sources & evidence

ORD record
ord-c3dbdb3659f34d54b31b0f21f5e811ab
Source dataset
uspto-grants-1998_10
Patent number
US05817671

Reaction notes

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