4-Fluorobenzoyl chloride → HCID 11069268, compound

HRID 398942Notes

Reaction equation

HRID 398942 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]2[C:8]([CH:11]3[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][CH3:20])[CH2:13][CH2:12]3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1.[F:21][C:22]1[CH:30]=[CH:29][C:25]([C:26](Cl)=[O:27])=[CH:24][CH:23]=1>>[F:21][C:22]1[CH:30]=[CH:29][C:25]([C:26]([NH:1][C:2]2[N:7]=[C:6]3[C:8]([CH:11]4[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][CH3:20])[CH2:13][CH2:12]4)=[CH:9][NH:10][C:5]3=[CH:4][CH:3]=2)=[O:27])=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 11119233HCID 11119233, compound

Product 1

HCID 11069268HCID 11069268, compoundYield 355.6%

Procedure

Beginning with 0.15 gm (0.55 mMol) 5-amino-3-(1-butyl-piperidin-4-yl)pyrrolo[3,2-b]pyridine and 0.079 mL (0.067 mMol) 4-fluorobenzoyl chloride, 0.094 gm (43%) of the title compound were prepared as an ivory foam essentially by the procedure described in Example 4. An analytical sample was crystallized from aqueous ethanol.

Sources & evidence

ORD record
ord-6fc8ed7eec5c4603b1a89eb7dd4c2d15
Source dataset
uspto-grants-1998_10
Patent number
US05817671

Reaction notes

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