4-Fluorobenzoyl chloride → HCID 19601568, compound

HRID 398953Notes

Reaction equation

HRID 398953 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]2[C:8]([C:11]3[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH:16]=3)=[CH:9][NH:10][C:5]2=[CH:4][CH:3]=1.[F:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1>>[F:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([NH:1][C:2]2[N:7]=[C:6]3[C:8]([C:11]4[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH:16]=4)=[CH:9][NH:10][C:5]3=[CH:4][CH:3]=2)=[O:24])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 10988008HCID 10988008, compound

Product 1

HCID 19601568HCID 19601568, compoundYield 84.3%

Procedure

Beginning with 0.200 gm (0.88 mMol) 5-amino-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)pyrrolo[3,2-b]pyridine and 0.114 mL (0.96 mMol) 4-fluorobenzoyl chloride, 0.260 gm (84%) of the title compound were prepared as an ivory solid essentially by the procedure described in Example 4. An analytical sample was crystallized from aqueous ethanol.

Sources & evidence

ORD record
ord-f662f45d53ca4469b8caca7dd725110c
Source dataset
uspto-grants-1998_10
Patent number
US05817671

Reaction notes

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