Tetrahydrofuran → Methyl 4'-[[2-butyl-4-quinolinyl]-methyl]1,1'-biphenyl-2-carboxylate

Participants

Reaction Steps

Using the procedure of Step G of Example 1, 500 mg of 2-butyl-4-chloro quinoline of Step D were introduced into a previously prepared solution of 475 mg of electrolytic zinc, 275 mg of tetrakistriphenyl-phosphine palladium and 2.075 g of [[2'-(methoxycarbonyl)(1,1'-biphenyl)-4-yl]-methyl zinc bromide prepared as in Example 1 in 13 ml of tetrahydrofuran. After chromatographing on silica (eluant:choloroform-hexane-ethyl acetate 100-100-10), 621 mg of the expected product were obtained.

Provenance & Evidence