Acetic Acid → HCID 19595325, compound

HRID 398998Notes

Reaction equation

HRID 398998 reaction equation
[CH2:1]([C:5]1[C:14](=[O:15])[C:13]2[CH2:12][CH:11]([CH3:16])[CH2:10][CH2:9][C:8]=2[N:7]([C:17]2[C:18]([CH3:32])=[C:19](C([O-])=O)[C:20](C3C=CC=CC=3)=[CH:21][CH:22]=2)[CH:6]=1)[CH2:2][CH2:3][CH3:4].[C:33]([OH:36])(=[O:35])[CH3:34]>[OH-].[Na+]>[CH2:1]([C:5]1[C:14](=[O:15])[C:13]2[CH2:12][CH:11]([CH3:16])[CH2:10][CH2:9][C:8]=2[N:7]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([C:6]3[C:34]([C:33]([OH:36])=[O:35])=[CH:3][CH:2]=[CH:1][CH:5]=3)=[CH:22][CH:32]=2)[CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 131720858HCID 131720858, compound

Product 1

HCID 19595325HCID 19595325, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
60 °C

Procedure

Using the procedure of Example 31, 0.4 g of product A of Example 32 in 10 ml of 2N sodium hydroxide were reacted. The mixture was stirred over-night at about 60° C. and the medium was cooled to ambient temperature, acidified with glacial acetic acid, decanted, impasted in a solution of 2N hydrochloric acid, separated, dried and crystallized from 50 ml of an ethanol-water 49-1 mixture to obtain 0.220 g of the expected product melting at 255° C.

Workup

  1. customwere reacted
  2. temperaturethe medium was cooled to ambient temperature
  3. customdecanted
  4. customseparated
  5. customdried
  6. customcrystallized from 50 ml of an ethanol-water 49-1 mixture

Sources & evidence

ORD record
ord-8610e5f96dff445a8d37360d38be673e
Source dataset
uspto-grants-1998_10
Patent number
US05817674

Reaction notes

Loading…