Pyridine → HCID 18969790, compound

Participants

Reaction Steps

To a solution of Example 62 (150 mg) in CH2Cl2 (3 mL) at r.t., was added pyridine (370 mL), Ac2O (215 μL) and DMAP (5 mg). The mixture was stirred at r.t. for 2 hr and diluted with EtOAc and H2O. The organic phase was washed with HCl 1N, brine, dried (MgSO4) and the solvents evaporated. The residue was purified by flash chromatography (silica gel; hexane/EtOAc (70:30)) to give the title compound as a white solid, m.p. 60°-61° C.

Provenance & Evidence