Phenyl isocyanate → HCID 131720864, compound

Participants

Reaction Steps

To a solution of Example 62 (150 mg) in toluene (2.3 mL) at r.t., was added diisopropylethylamine (160 μL) and phenylisocyanate (100 μL ). The mixture was refluxed for 4 hr, cooled to r.t. and diluted with EtOAc and H2O. The organic phase was washed with HCl 1N, brine, dried (MgSO4) and the solvents evaporated. The residue was purified by flash chromatography (silica gel; hexane/EtOAc (80:20 to 60:40)) to give the title compound as a white solid, m.p. 85.5°-87° C.

Provenance & Evidence