Potassium Hydroxide → HCID 178515829, compound

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Reaction Steps

Compound 53 (8.5 mg, 0.044 mmol) was dissolved in 1 ml tert-butanol. To this solution was added 1 ml 2M potassium hydroxide. After reflux for 20 hours and evaporation of butanol, the mixture was adjusted with 1M hydrochloric acid to pH 6-7. Evaporation of solvent in vacuo and purification of product with silica gel preparative thin layer chromatography developing with 20% 7N ammonia methanol in chloroform gave 4.2 mg compound 77 as an oil. Yield 50%. MS(CI) 191(M+1). 1H-NMR (CDCl3) δ 2.554 (br.s., 1H, H2), 3.503; 3.743 (2br.s., 2H, H1,4).

Provenance & Evidence