Iodine → HCID 12786936, compound

HRID 399143Notes

Reaction equation

HRID 399143 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([Br:10])[N:5]=1)(=[O:3])[CH3:2].[I:11]I>N1C=CC=CC=1>[I-:11].[Br:10][C:6]1[N:5]=[C:4]([C:1](=[O:3])[CH2:2][N+:5]2[CH:6]=[CH:7][CH:8]=[CH:9][CH:4]=2)[CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 807IodineHCID 112985782-Acetyl-6-bromopyridine

Product 1

HCID 12786936HCID 12786936, compoundYield 167.9%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 2-acetyl-6-bromopyridine (0.075 mol), 25 ml of pyridine, and iodine (0.075 mol) was allowed to react at 100° C. for 45 minutes and then cooled to room temperature. The reaction mixture was filtered, the solid product was triturated with CH2Cl2 (200 ml), isolated by filtration, and the residual solvent was removed under vacuum to yield 25.5 g (85%) of the desired salt. Melting point: 176°-178° C.

Workup

  1. customto react at 100° C. for 45 minutes
  2. filtrationThe reaction mixture was filtered
  3. customthe solid product was triturated with CH2Cl2 (200 ml)
  4. customisolated by filtration
  5. customthe residual solvent was removed under vacuum

Sources & evidence

ORD record
ord-a776590251bf4765b63bab6d99fdbaaf
Source dataset
uspto-grants-1998_10
Patent number
US05817774

Reaction notes

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